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Imaging the encephalopathy of prematurityJulia Kline and colleagues assessed MRI findings at term in 110 http://cz.keimfarben.de/buy-lasix-online-usa/ preterm lasix prices walmart infants born before 32 weeks’ gestation and cared for in four neonatal units in Columbus, Ohio. Using automated cortical and sub-cortical segmentation they analysed cortical surface area, sulcal depth, gyrification index, inner cortical curvature and thickness. These measures of brain development and maturation were related to the outcomes of cognitive and language lasix prices walmart testing undertaken at 2 years corrected age using the Bayley-III.

Increased surface area in nearly every brain region was positively correlated with Bayley-III cognitive and language scores. Increased inner cortical curvature was negatively correlated with both outcomes. Gyrification index and sulcal lasix prices walmart depth did not follow consistent trends.

These metrics retained their significance after sex, gestational age, socio-economic status and global injury score on structural MRI were included in the analysis. Surface area and inner cortical curvature explained approximately one-third of the variance in Bayley-III scores.In an accompanying editorial, David Edwards characterises the complexity of imaging and interpreting the combined effects of injury and dysmaturation on the developing brain. Major structural lesions are present in a minority of infants and the problems observed in later childhood require a much lasix prices walmart broader understanding of the effects of prematurity on brain development.

Presently these more sophisticated image-analysis techniques provide insights at a population level but the variation between individuals is such that they are not sufficiently predictive at an individual patient level to be of practical use to parents or clinicians in prognostication. Studies like this highlight the importance of follow-up programmes and help clinicians to avoid falling into the trap of equating normal (no major structural lesion) imaging studies with normal long term outcomes. See pages F460 and F458Drift at 10 yearsKaren Luuyt and colleagues report the cognitive outcomes at 10 years of the DRIFT (drainage, irrigation and fibrinolytic therapy) lasix prices walmart randomised controlled trial of treatment for post haemorrhagic ventricular dilatation.

They are to be congratulated for continuing to track these children and confirming the persistence of the cognitive advantage of the treatment that was apparent from earlier follow-up. Infants who received DRIFT were almost twice as likely to survive without severe cognitive lasix prices walmart disability than those who received standard treatment. While the confidence intervals were wide, the point estimate suggests that the number needed to treat for DRIFT to prevent one death or one case of severe cognitive disability was 3.

The original trial took place between 2003 and 2006 and was stopped early because of concerns about secondary intraventricular haemorrhage and it was only on follow-up that the advantages of the treatment became apparent. The study shows that secondary brain injury can be reduced by washing away the lasix prices walmart harmful debris of IVH. No other treatment for post-haemorrhagic ventricular dilatation has been shown to be beneficial in a randomised controlled trial.

Less invasive approaches to CSF drainage at different thresholds of ventricular enlargement later in the clinical course have not been associated with similar advantage. However the DRIFT treatment is complex and invasive and lasix prices walmart could only be provided in a small number of specialist referral centres and logistical challenges will need to be overcome to evaluate the treatment approach further. See page F466Chest compressionsWith a stable infant in the neonatal unit, it is common to review the events of the initial stabilisation and to speculate on whether chest compressions were truly needed to establish an effective circulation, or whether their use reflected clinician uncertainty in the face of other challenges.

Anne Marthe Boldinge and colleagues provide some objective data on the subject. They analysed videos that were recorded during neonatal stabilisation in a single centre with lasix prices walmart 5000 births per annum. From a birth population of almost 1200 infants there were good quality video recordings from 327 episodes of initial stabilisation where positive pressure ventilation was provided and 29 of these episodes included the provision of chest compressions, mostly in term infants.

6/29 of the infants who received chest compressions were retrospectively judged to have needed them. 8/29 had adequate spontaneous respiration lasix prices walmart. 18/29 received ineffective positive pressure ventilation prior to chest compressions.

5/29 had a heart rate greater than 60 beats per minute at the time of chest compressions lasix prices walmart. A consistent pattern of ventilation corrective actions was not identified. One infant received chest compressions without prior heart rate assessment.

See page 545Propofol for neonatal endotracheal intubationMost clinicians provide sedation/analgesia for neonatal intubations but there is still a lasix prices walmart lot of uncertainty about the best approach. Ellen de Kort and colleagues set out to identify the dose of propofol that would provide adequate sedation for neonatal intubation without side-effects. They conducted a dose-finding trial which evaluated a range of doses in infants of different gestations.

They ended their study after 91 infants because they only achieved lasix prices walmart adequate sedation without side effects in 13% of patients. Hypotension (mean blood pressure below post-mentrual age in the hour after treatment) was observed in 59% of patients. See page 489Growth to early adulthood following extremely preterm birthThe EPICure cohort comprised all babies born at 25 completed weeks of gestation or less in all 276 maternity units in the UK and Ireland from March to December 1995.

Growth data lasix prices walmart into adulthood are sparse for such immature infants. Yanyan Ni and colleagues report the growth to 19 years of 129 of the cohort in comparison with contemporary term born controls. The extremely preterm infants were on average 4.0 cm lasix prices walmart shorter and 6.8 kg lighter with a 1.5 cm smaller head circumference relative to controls at 19 years.

Body mass index was significantly elevated to +0.32 SD. With practice changing to include the provision of life sustaining treatment to greater numbers of infants born at 22 and 23 weeks of gestation there is a strong case for further cohort studies to include this population of infants. See page F496Premature birth is a worldwide problem, and the most significant lasix prices walmart cause of loss of disability-adjusted life years in children.

Impairment and disability among survivors are common. Cerebral palsy is diagnosed in around 10% of infants born before 33 weeks of gestation, although the rates approximately double in the smallest and most vulnerable infants, and other motor disturbances are being detected in 25%–40%. Cognitive, socialisation and behavioural problems are apparent in lasix prices walmart around half of preterm infants, and there is increased incidence of neuropsychiatric disorders, which develop as the children grow older.

Adults born preterm are approximately seven times more likely to be diagnosed with bipolar disease.1 2The neuropathological basis for these long-term and debilitating disorders is often unclear. Brain imaging by ultrasound or MRI shows that only a relatively small proportion of infants have significant destructive brain lesions, and these major lesions are not detected commonly enough to account for the prevalence of long-term impairments. However, abnormalities of brain lasix prices walmart growth and maturation are common, and it is now apparent that, in addition to recognisable cerebral damage, adverse neurological, cognitive and psychiatric outcomes are consistently associated with abnormal cerebral maturation and development.Currently, most clinical decision-making remains focused around a number of well-described cerebral lesions usually detected in routine practice using cranial ultrasound.

Periventricular haemorrhage is common. Severe haemorrhages are associated with long-term adverse outcomes, and in infants born before 33 weeks of gestation, haemorrhagic parenchymal infarction predicts motor deficits ….

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Full time FTC up can lasix give you diarrhea to 24 monthsThe Birmingham Medical School seeks to appoint a Lecturer in Medical Education. The newly appointed Lecturer will contribute to the delivery and development of the undergraduate Medicine (MB ChB) programme and postgraduate Education for Health Care Professions (E4HP). The Lecturer will be an experienced educator with an established track record in curriculum design and implementation, assessment and an interest in digital education to continue to innovate and deliver a first class education for future doctors and practising health care professionals Some of the Main duties  Contribute to MB ChB curriculum development and renewal working with staff in the College of Medical and Dental Sciences and with colleagues in our Local Education Partnerships Trusts and General Practices Develop and manage approaches to teaching and learning that are innovative to the subject area and take account of the challenges of delivery during the lasixContribute to the development of existing and novel assessment methodology that can be delivered within the current challengesDeliver teaching on specific modules of the MB ChB and E4HPLearning and Teaching To use a variety of methods teaching and advising individuals and groups of undergraduates and postgraduates to include a strong focus on online development and delivery of materialsTeach and can lasix give you diarrhea examine courses at a range of levels and in response to the ongoing challenges of the lasixPlan and review own teaching approaches and acting as a mentor to encourage others to do the sameManagement and Administration Contribute to the administration/management of teaching and assessment across MB ChB and E4HP Contribute to the implementation of the MB ChB curriculum reviewPerson Specification Normally, a higher Degree relevant to the discipline area (usually PhD) or equivalent qualifications.Extensive teaching experience and scholarship within subject specialism.Proven ability to devise, advise on and manage learning and assessment including in digital formSkills in managing, motivating &. Mentoring others successfully at all levels.Teaching Ability to design, deliver, assess and revise teaching programmes.

Experience and demonstrated success in developing appropriate approaches to learning and teaching and advising colleagues Experience and achievement in knowledge transfer, enterprise and similar activity that enhances the student experience or employabilityAbility to develop high quality on line teaching and assessment can lasix give you diarrhea materialsManagement Administration Ability to contribute to School/Departmental management processesAbility to assess and organise resources effectivelyInformal Enquiries Prof Una Martin PA Lou Bagley Email. L.bagley@bham.ac.uk Full time starting salary is normally in the range £41,526 to £49,553, with potential progression once in post to £55,750. Closing date: 25/11/20 Reference can lasix give you diarrhea. 95785 To download the full job description and details of this position and submit an electronic application online please click on the Apply Online button below or visit our careers website.

Https://bham.taleo.net/careersection/external/jobsearch.ftl?. Lang=en&portal=101430233, please quote Job Ref 95785 in all enquiries. Valuing excellence. Sustaining investment We value diversity at The University of Birmingham and welcome applications from all sections of the community’An exciting opportunity has become available for a Clinical Trial Practitioner (Maternity Cover) to join our team to participate in the planning and management of clinical research studies and clinical trials in Oncology and care for patients recruited for such studies.

You will support several different types of studies from blood collection studies to phase 1 clinical trials. We are a small translational research team working at the Charing Cross Campus. We’re working on various cancer types including breast, prostate and ovarian cancer. We manage a mixed portfolio of tissue collections studies, early phase clinical trials as well as oncology surgical studies.

Our portfolio consists of mostly academic studies which we oversee from both the site and Sponsor perspectives. Our team is energetic and resourceful and are often involved in developing new studies from concept with our clinicians and scientists. We are looking for an individual with a desire to work autonomously with initiative while supporting team members to cover a diverse portfolio of academics oncology studies. Duties Duties and responsibilities will be a mix of both clinical and research responsibilities as outlined below.

Clinical You will support patients receiving a diagnosis of cancer and helping them through a decision-making process concerning their treatment and possible participation on a research study.You will be proficient in taking patient samples, centrifuging and processing samples according to safe lab practice.You will provide teaching sessions and resource files to Trust departments involved in studies. Research You will be familiar with and keep yourself informed of ICH GCP, EU Directives, Declaration of Helsinki and the Research Governance Framework.You will assist with recruitment of patients by developing and using effective recruitment strategies within the MDT and screening all clinic lists.You will attend clinic visits with trial patients, to ensure assessments/treatments are conducted as per the protocol.You will assist with the preparation and submission of ethics applications for new studies and amendments as well as any SSI forms for local studies. Essential requirements You will have proven clinical or management experience working in oncology or a similar unit-based environment. You will have previous experience of research, audit and quality initiatives.

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For technical issues when applying online please email recruitment@imperial.ac.uk As this post is exempt from the Rehabilitation of Offenders Act 1974, a satisfactory Disclosure and Barring Service (DBS) check, at the appropriate level, will be required for the successful candidate. Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people. Closing date.

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Full time lasix prices walmart FTC up to 24 monthsThe Birmingham Medical School seeks to appoint a Lecturer in Medical Education. The newly appointed Lecturer will contribute to the delivery and development of the undergraduate Medicine (MB ChB) programme and postgraduate Education for Health Care Professions (E4HP). The Lecturer will be an experienced educator with an established track record in curriculum design and implementation, assessment and an interest in digital education to continue to innovate and deliver a first class education for future doctors and practising health care professionals Some of the Main duties  Contribute to MB ChB curriculum development and renewal working with staff in the College of Medical and Dental Sciences and with colleagues in our Local Education lasix prices walmart Partnerships Trusts and General Practices Develop and manage approaches to teaching and learning that are innovative to the subject area and take account of the challenges of delivery during the lasixContribute to the development of existing and novel assessment methodology that can be delivered within the current challengesDeliver teaching on specific modules of the MB ChB and E4HPLearning and Teaching To use a variety of methods teaching and advising individuals and groups of undergraduates and postgraduates to include a strong focus on online development and delivery of materialsTeach and examine courses at a range of levels and in response to the ongoing challenges of the lasixPlan and review own teaching approaches and acting as a mentor to encourage others to do the sameManagement and Administration Contribute to the administration/management of teaching and assessment across MB ChB and E4HP Contribute to the implementation of the MB ChB curriculum reviewPerson Specification Normally, a higher Degree relevant to the discipline area (usually PhD) or equivalent qualifications.Extensive teaching experience and scholarship within subject specialism.Proven ability to devise, advise on and manage learning and assessment including in digital formSkills in managing, motivating &.

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Closing date: 25/11/20 Reference lasix prices walmart. 95785 To download the full job description and details of this position and submit an electronic application online please click on the Apply Online button below or visit our careers website. Https://bham.taleo.net/careersection/external/jobsearch.ftl?.

Lang=en&portal=101430233, please quote Job Ref 95785 in all enquiries. Valuing excellence. Sustaining investment We value diversity at The University of Birmingham and welcome applications from all sections of the community’An exciting opportunity has become available for a Clinical Trial Practitioner (Maternity Cover) to join our team to participate in the planning and management of clinical research studies and clinical trials in Oncology and care for patients recruited for such studies.

You will support several different types of studies from blood collection studies to phase 1 clinical trials. We are a small translational research team working at the Charing Cross Campus. We’re working on various cancer types including breast, prostate and ovarian cancer.

We manage a mixed portfolio of tissue collections studies, early phase clinical trials as well as oncology surgical studies. Our portfolio consists of mostly academic studies which we oversee from both the site and Sponsor perspectives. Our team is energetic and resourceful and are often involved in developing new studies from concept with our clinicians and scientists.

We are looking for an individual with a desire to work autonomously with initiative while supporting team members to cover a diverse portfolio of academics oncology studies. Duties Duties and responsibilities will be a mix of both clinical and research responsibilities as outlined below. Clinical You will support patients receiving a diagnosis of cancer and helping them through a decision-making process concerning their treatment and possible participation on a research study.You will be proficient in taking patient samples, centrifuging and processing samples according to safe lab practice.You will provide teaching sessions and resource files to Trust departments involved in studies.

Research You will be familiar with and keep yourself informed of ICH GCP, EU Directives, Declaration of Helsinki and the Research Governance Framework.You will assist with recruitment of patients by developing and using effective recruitment strategies within the MDT and screening all clinic lists.You will attend clinic visits with trial patients, to ensure assessments/treatments are conducted as per the protocol.You will assist with the preparation and submission of ethics applications for new studies and amendments as well as any SSI forms for local studies. Essential requirements You will have proven clinical or management experience working in oncology or a similar unit-based environment. You will have previous experience of research, audit and quality initiatives.

You will have experience of phlebotomy or willingness to complete training in phlebotomy and you will be expected to undergo any other training as required. You will have the discipline and regard for confidentiality, safety and security at all times. Further Information The post is full time, fixed term for 12 months from 1st February 2021.

For further information, please contact Ms Kelly Gleason (k.gleason@imperial.ac.uk). For technical issues when applying online please email recruitment@imperial.ac.uk As this post is exempt from the Rehabilitation of Offenders Act 1974, a satisfactory Disclosure and Barring Service (DBS) check, at the appropriate level, will be required for the successful candidate. Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment.

We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people. Closing date. 19/11/2020 To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED02078..

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The New Zealand Maternity Clinical Indicators present lasix not urinating comparative maternity interventions and outcomes data across a set of 20 indicators for pregnant women and their babies by maternity facility and district health board region. One indicator applies to women who registered with a lead maternity carer (LMC). Eight indicators apply to standard primiparae (definition used to identify a group of women for whom interventions and outcomes should be similar).

Seven indicators apply to all women giving birth in lasix not urinating New Zealand. Four apply to all babies born in New Zealand. This is the tenth year in the New Zealand Maternity Clinical Indicators series, with a focus on women giving birth and babies born in the 2018 calendar year.

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The report gives an overview of the occupation and demographics of lasix not urinating health care and support workers diagnosed with hypertension medications with a focus on transmission pathways in the workplace. This report is descriptive and is therefore not able to explain how transmission occurred. It provides valuable information we can apply and touches on some of the work that is underway at the time of publication to address those areas..

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This is the tenth year in the New Zealand Maternity Clinical Indicators series, with a focus on women giving birth and babies born in the 2018 calendar year. As the previous years’ data demonstrated, reported lasix prices walmart maternity service delivery and outcomes for women and babies vary between district health boards (DHBs) and between individual secondary and tertiary facilities. These findings merit further investigation of data quality and integrity as well as variations in local clinical practice management. Since 2012, DHBs and maternity stakeholders have used national benchmarked data in their local maternity quality and safety programs to identify areas warranting further investigation. To support further investigation, the Ministry of Health provides unit record clinical indicators data to DHB maternity quality lasix prices walmart and safety programme coordinators.

Access the data A web-based tool is available for you to explore the numbers and rates for 2018 and trends across the full 10-year time series. This includes numbers and rates of each indicator from 2009 to 2018 by ethnic group and DHB of residence, and by facility of birth. The same data is lasix prices walmart also available as an Excel file. Trends. Graphs and summary tables (Excel, 3.4 MB).

The Ministry lasix prices walmart of Health is no longer producing the New Zealand Maternity Clinical Indicators Report. The web-based tool provides the full indicators dataset as tables and figures. Background, methodology and metadata are available in the following guide:Health care and support workers are an essential and valuable workforce. The nature of their occupation or workplace means they may be at increased risk of contracting hypertension medications during a time of lasix prices walmart community transmission. The first case of hypertension medications in a health care or support worker was reported on 17 March 2020.

After exclusions, 167 people diagnosed with hypertension medications were recorded as health care and support workers during the ‘first wave’ of the lasix in Aotearoa New Zealand, as at 12 June. The report gives an overview of the occupation and demographics of health care and support workers diagnosed with hypertension medications lasix prices walmart with a focus on transmission pathways in the workplace. This report is descriptive and is therefore not able to explain how transmission occurred. It provides valuable information we can apply and touches on some of the work that is underway at the time of publication to address those areas..

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Start Preamble Notice of amendment healthy alternative to lasix. The Secretary issues this amendment pursuant to section 319F-3 of the Public Health Service Act to add additional categories of Qualified Persons and amend the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures. This amendment to the Declaration published on March 17, 2020 (85 FR 15198) is effective as of August 24, 2020 healthy alternative to lasix. Start Further Info Robert P. Kadlec, MD, MTM&H, MS, Assistant Secretary for Preparedness and Response, Office of healthy alternative to lasix the Secretary, Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201.

Telephone. 202-205-2882. End Further Info End Preamble Start Supplemental Information The Public Readiness and Emergency Preparedness Act (PREP Act) authorizes the Secretary of Health and Human Services (the Secretary) to issue a Declaration to provide liability immunity to certain individuals and entities (Covered Persons) against any claim of loss caused by, arising out of, relating to, or resulting from the manufacture, distribution, administration, or use of medical countermeasures (Covered Countermeasures), except for claims involving “willful misconduct” as defined in the PREP Act. Under the PREP Act, a Declaration may be amended as circumstances warrant. The PREP Act was enacted on December 30, 2005, as Public Law 109-148, Division C, § 2.

It amended the Public Health Service (PHS) Act, adding section 319F-3, which addresses liability immunity, and section 319F-4, which creates a compensation program. These sections are codified at 42 U.S.C. 247d-6d and 42 U.S.C. 247d-6e, respectively. Section 319F-3 of the PHS Act has been amended by the lasix and All-Hazards Preparedness Reauthorization Act (PAHPRA), Public Law 113-5, enacted on March 13, 2013 and the hypertension Aid, Relief, and Economic Security (CARES) Act, Public Law 116-136, enacted on March 27, Start Printed Page 521372020, to expand Covered Countermeasures under the PREP Act.

On January 31, 2020, the Secretary declared a public health emergency pursuant to section 319 of the PHS Act, 42 U.S.C. 247d, effective January 27, 2020, for the entire United States to aid in the response of the nation's health care community to the hypertension medications outbreak. Pursuant to section 319 of the PHS Act, the Secretary renewed that declaration on April 26, 2020, and July 25, 2020. On March 10, 2020, the Secretary issued a Declaration under the PREP Act for medical countermeasures against hypertension medications (85 FR 15198, Mar. 17, 2020) (the Declaration).

On April 10, the Secretary amended the Declaration under the PREP Act to extend liability immunity to covered countermeasures authorized under the CARES Act (85 FR 21012, Apr. 15, 2020). On June 4, the Secretary amended the Declaration to clarify that covered countermeasures under the Declaration include qualified countermeasures that limit the harm hypertension medications might otherwise cause. The Secretary now amends section V of the Declaration to identify as qualified persons covered under the PREP Act, and thus authorizes, certain State-licensed pharmacists to order and administer, and pharmacy interns (who are licensed or registered by their State board of pharmacy and acting under the supervision of a State-licensed pharmacist) to administer, any treatment that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule (ACIP-recommended treatments).[] The Secretary also amends section VIII of the Declaration to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures includes not only hypertension medications caused by hypertension or a lasix mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by hypertension medications, hypertension, or a lasix mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases. Description of This Amendment by Section Section V.

Covered Persons Under the PREP Act and the Declaration, a “qualified person” is a “covered person.” Subject to certain limitations, a covered person is immune from suit and liability under Federal and State law with respect to all claims for loss caused by, arising out of, relating to, or resulting from the administration or use of a covered countermeasure if a declaration under subsection (b) has been issued with respect to such countermeasure. €œQualified person” includes (A) a licensed health professional or other individual who is authorized to prescribe, administer, or dispense such countermeasures under the law of the State in which the countermeasure was prescribed, administered, or dispensed. Or (B) “a person within a category of persons so identified in a declaration by the Secretary” under subsection (b) of the PREP Act. 42 U.S.C. 247d-6d(i)(8).[] By this amendment to the Declaration, the Secretary identifies an additional category of persons who are qualified persons under section 247d-6d(i)(8)(B).[] On May 8, 2020, CDC reported, “The identified declines in routine pediatric treatment ordering and doses administered might indicate that U.S.

Children and their communities face increased risks for outbreaks of treatment-preventable diseases,” and suggested that a decrease in rates of routine childhood vaccinations were due to changes in healthcare access, social distancing, and other hypertension medications mitigation strategies.[] The report also stated that “[p]arental concerns about potentially exposing their children to hypertension medications during well child visits might contribute to the declines observed.” [] On July 10, 2020, CDC reported its findings of a May survey it conducted to assess the capacity of pediatric health care practices to provide immunization services to children during the hypertension medications lasix. The survey, which was limited to practices participating in the treatments for Children program, found that, as of mid-May, 15 percent of Northeast pediatric practices were closed, 12.5 percent of Midwest practices were closed, 6.2 percent of practices in the South were closed, and 10 percent of practices in the West were closed. Most practices had reduced office hours for in-person visits. When asked whether their practices would likely be able to accommodate new patients for immunization services through August, 418 practices (21.3 percent) either responded that this was not likely or the practice was permanently closed or not resuming immunization services for all patients, and 380 (19.6 percent) responded that they were unsure. Urban practices and those in the Northeast were less likely to be able to accommodate new patients compared with rural practices and those in the South, Midwest, or West.[] In response to these troubling developments, CDC and the American Academy of Pediatrics have stressed, “Well-child visits and vaccinations are essential services and help make sure children are protected.” [] The Secretary re-emphasizes that important recommendation to parents and legal guardians here.

If your child is due for a well-child visit, contact your pediatrician's or other primary-care provider's office and ask about ways that the office safely offers well-child visits and vaccinations. Many medical offices are taking extra steps to make sure that well-child visits can occur safely during the hypertension medications lasix, including. Scheduling sick visits and well-child visits during different times of the Start Printed Page 52138day or days of the week, or at different locations. Asking patients to remain outside until it is time for their appointments to reduce the number of people in waiting rooms. Adhering to recommended social (physical) distancing and other -control practices, such as the use of masks.

The decrease in childhood-vaccination rates is a public health threat and a collateral harm caused by hypertension medications. Together, the United States must turn to available medical professionals to limit the harm and public health threats that may result from decreased immunization rates. We must quickly do so to avoid preventable s in children, additional strains on our healthcare system, and any further increase in avoidable adverse health consequences—particularly if such complications coincide with additional resurgence of hypertension medications. Together with pediatricians and other healthcare professionals, pharmacists are positioned to expand access to childhood vaccinations. Many States already allow pharmacists to administer treatments to children of any age.[] Other States permit pharmacists to administer treatments to children depending on the age—for example, 2, 3, 5, 6, 7, 9, 10, 11, or 12 years of age and older.[] Few States restrict pharmacist-administered vaccinations to only adults.[] Many States also allow properly trained individuals under the supervision of a trained pharmacist to administer those treatments.[] Pharmacists are well positioned to increase access to vaccinations, particularly in certain areas or for certain populations that have too few pediatricians and other primary-care providers, or that are otherwise medically underserved.[] As of 2018, nearly 90 percent of Americans lived within five miles of a community pharmacy.[] Pharmacies often offer extended hours and added convenience.

What is more, pharmacists are trusted healthcare professionals with established relationships with their patients. Pharmacists also have strong relationships with local medical providers and hospitals to refer patients as appropriate. For example, pharmacists already play a significant role in annual influenza vaccination. In the early 2018-19 season, they administered the influenza treatment to nearly a third of all adults who received the treatment.[] Given the potential danger of serious influenza and continuing hypertension medications outbreaks this autumn and the impact that such concurrent outbreaks may have on our population, our healthcare system, and our whole-of-nation response to the hypertension medications lasix, we must quickly expand access to influenza vaccinations. Allowing more qualified pharmacists to administer the influenza treatment to children will make vaccinations more accessible.

Therefore, the Secretary amends the Declaration to identify State-licensed pharmacists (and pharmacy interns acting under their supervision if the pharmacy intern is licensed or registered by his or her State board of pharmacy) as qualified persons under section 247d-6d(i)(8)(B) when the pharmacist orders and either the pharmacist or the supervised pharmacy intern administers treatments to individuals ages three through 18 pursuant to the following requirements. The treatment must be FDA-authorized or FDA-approved. The vaccination must be ordered and administered according to ACIP's standard immunization schedule.[] The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training Start Printed Page 52139program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation.[] The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.[] The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment.[] The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregivers accompanying the children of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate.[] These requirements are consistent with those in many States that permit licensed pharmacists to order and administer treatments to children and permit licensed or registered pharmacy interns acting under their supervision to administer treatments to children.[] Administering vaccinations to children age three and older is less complicated and requires less training and resources than administering vaccinations to younger children.

That is because ACIP generally recommends administering intramuscular injections in the deltoid muscle for individuals age three and older.[] For individuals less than three years of age, ACIP generally recommends administering intramuscular injections in the anterolateral aspect of the thigh muscle.[] Administering injections in the thigh muscle often presents additional complexities and requires additional training and resources including additional personnel to safely position the child while another healthcare professional injects the treatment.[] Moreover, as of 2018, 40% of three-year-olds were enrolled in preprimary programs (i.e. Preschool or kindergarten programs).[] Preprimary programs are beginning in the coming weeks or months, so the Secretary has concluded that it is particularly important for individuals ages three through 18 to receive ACIP-recommended treatments according to ACIP's standard immunization schedule. All States require children to be vaccinated against certain communicable diseases as a condition of school attendance. These laws often apply to both public and private schools with identical immunization and exemption provisions.[] As nurseries, preschools, kindergartens, and schools reopen, increased access to childhood vaccinations is essential to ensuring children can return. Notwithstanding any State or local scope-of-practice legal requirements, (1) qualified licensed pharmacists are identified as qualified persons to order and administer ACIP-recommended treatments and (2) qualified State-licensed or registered pharmacy interns are identified as qualified persons to administer the ACIP-recommended treatments ordered by their supervising qualified licensed pharmacist.[] Both the PREP Act and the June 4, 2020 Second Amendment to the Declaration define “covered countermeasures” to include qualified lasix and epidemic products that “limit the harm such lasix or epidemic might otherwise cause.” [] The troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by Start Printed Page 52140hypertension medications as set forth in Sections VI and VIII of this Declaration.[] Hence, such vaccinations are “covered countermeasures” under the PREP Act and the June 4, 2020 Second Amendment to the Declaration.

Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program. Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C. 300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program. All other terms and conditions of the Declaration apply to such covered countermeasures.

Section VIII. Category of Disease, Health Condition, or Threat As discussed, the troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by hypertension medications. The Secretary therefore amends section VIII, which describes the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures, to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures is not only hypertension medications caused by hypertension or a lasix mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by hypertension medications, hypertension, or a lasix mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases. Amendments to Declaration Amended Declaration for Public Readiness and Emergency Preparedness Act Coverage for medical countermeasures against hypertension medications. Sections V and VIII of the March 10, 2020 Declaration under the PREP Act for medical countermeasures against hypertension medications, as amended April 10, 2020 and June 4, 2020, are further amended pursuant to section 319F-3(b)(4) of the PHS Act as described below.

All other sections of the Declaration remain in effect as published at 85 FR 15198 (Mar. 17, 2020) and amended at 85 FR 21012 (Apr. 15, 2020) and 85 FR 35100 (June 8, 2020). 1. Covered Persons, section V, delete in full and replace with.

V. Covered Persons 42 U.S.C. 247d-6d(i)(2), (3), (4), (6), (8)(A) and (B) Covered Persons who are afforded liability immunity under this Declaration are “manufacturers,” “distributors,” “program planners,” “qualified persons,” and their officials, agents, and employees, as those terms are defined in the PREP Act, and the United States. In addition, I have determined that the following additional persons are qualified persons. (a) Any person authorized in accordance with the public health and medical emergency response of the Authority Having Jurisdiction, as described in Section VII below, to prescribe, administer, deliver, distribute or dispense the Covered Countermeasures, and their officials, agents, employees, contractors and volunteers, following a Declaration of an emergency.

(b) any person authorized to prescribe, administer, or dispense the Covered Countermeasures or who is otherwise authorized to perform an activity under an Emergency Use Authorization in accordance with Section 564 of the FD&C Act. (c) any person authorized to prescribe, administer, or dispense Covered Countermeasures in accordance with Section 564A of the FD&C Act. And (d) a State-licensed pharmacist who orders and administers, and pharmacy interns who administer (if the pharmacy intern acts under the supervision of such pharmacist and the pharmacy intern is licensed or registered by his or her State board of pharmacy), treatments that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule. Such State-licensed pharmacists and the State-licensed or registered interns under their supervision are qualified persons only if the following requirements are met. The treatment must be FDA-authorized or FDA-approved.

The vaccination must be ordered and administered according to ACIP's standard immunization schedule. The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments. The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.

The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation. The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period. The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment. The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregiver accompanying the child of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate. Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program.

Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C. 300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program. All other Start Printed Page 52141terms and conditions of the Declaration apply to such covered countermeasures. 2.

Category of Disease, Health Condition, or Threat, section VIII, delete in full and replace with. VIII. Category of Disease, Health Condition, or Threat 42 U.S.C. 247d-6d(b)(2)(A) The category of disease, health condition, or threat for which I recommend the administration or use of the Covered Countermeasures is not only hypertension medications caused by hypertension or a lasix mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by hypertension medications, hypertension, or a lasix mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases. Start Authority 42 U.S.C.

247d-6d. End Authority Start Signature Dated. August 19, 2020. Alex M. Azar II, Secretary of Health and Human Services.

End Signature End Supplemental Information [FR Doc. 2020-18542 Filed 8-20-20. 4:15 pm]BILLING CODE 4150-03-PToday, the U.S. Department of Health and Human Services released Healthy People 2030, the nation's 10-year plan for addressing our most critical public health priorities and challenges. Since 1980, HHS's Office of Disease Prevention and Health Promotion has set measurable objectives and targets to improve the health and well-being of the nation.This decade, Healthy People 2030 features 355 core – or measurable – objectives with 10-year targets, new objectives related to opioid use disorder and youth e-cigarette use, and resources for adapting Healthy People 2030 to emerging public health threats like hypertension medications.

For the first time, Healthy People 2030 also sets 10-year targets for objectives related to social determinants of health."Healthy People was the first national effort to lay out a set of data-driven priorities for health improvement," said HHS Secretary Alex Azar. "Healthy People 2030 adopts a more focused set of objectives and more rigorous data standards to help the federal government and all of our partners deliver results on these important goals over the next decade."Healthy People has led the nation with its focus on social determinants of health, and continues to prioritize economic stability, education access and quality, health care access and quality, neighborhood and built environment, and social and community context as factors that influence health. Healthy People 2030 also continues to prioritize health disparities, health equity, and health literacy."Now more than ever, we need programs like Healthy People that set a shared vision for a healthier nation, where all people can achieve their full potential for health and well-being across the lifespan," said ADM Brett P. Giroir, MD, Assistant Secretary for Health. "hypertension medications has brought the importance of public health to the forefront of our national dialogue.

Achieving Healthy People 2030's vision would help the United States become more resilient to public health threats like hypertension medications."Healthy People 2030 emphasizes collaboration, with objectives and targets that span multiple sectors. A federal advisory committee of 13 external thought leaders and a workgroup of subject matter experts from more than 20 federal agencies contributed to Healthy People 2030, along with public comments received throughout the development process.The HHS Office of Disease Prevention and Health Promotion leads Healthy People in partnership with the National Center for Health Statistics at the Centers for Disease Control and Prevention, which oversees data in support of the initiative.HHS Secretary Alex M. Azar II, ADM Brett P. Giroir, MD, Assistant Secretary for Health, and U.S. Surgeon General Jerome M.

Adams, MD, MPH, and others from HHS and CDC will launch Healthy People 2030 during a webcast on August 18 at 1 pm (EDT) at https://www.hhs.gov/live. No registration is necessary. For more information about Healthy People 2030, visit https://healthypeople.gov..

Start Preamble Notice of amendment lasix prices walmart. The Secretary issues this amendment pursuant to section 319F-3 of the Public Health Service Act to add additional categories of Qualified Persons and amend the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures. This amendment to the Declaration lasix prices walmart published on March 17, 2020 (85 FR 15198) is effective as of August 24, 2020. Start Further Info Robert P.

Kadlec, MD, MTM&H, MS, Assistant Secretary for Preparedness and lasix prices walmart Response, Office of the Secretary, Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. Telephone. 202-205-2882. End Further Info End Preamble Start Supplemental Information The Public Readiness and Emergency Preparedness Act (PREP Act) authorizes the Secretary of Health and Human Services (the Secretary) to issue a Declaration to provide liability immunity to certain individuals and entities (Covered Persons) against any claim of loss caused by, arising out of, relating to, or resulting from the manufacture, distribution, administration, or use of medical countermeasures (Covered Countermeasures), except for claims involving “willful misconduct” as defined in the PREP Act.

Under the PREP Act, a Declaration may be amended as circumstances warrant. The PREP Act was enacted on December 30, 2005, as Public Law 109-148, Division C, § 2. It amended the Public Health Service (PHS) Act, adding section 319F-3, which addresses liability immunity, and section 319F-4, which creates a compensation program. These sections are codified at 42 U.S.C.

247d-6d and 42 U.S.C. 247d-6e, respectively. Section 319F-3 of the PHS Act has been amended by the lasix and All-Hazards Preparedness Reauthorization Act (PAHPRA), Public Law 113-5, enacted on March 13, 2013 and the hypertension Aid, Relief, and Economic Security (CARES) Act, Public Law 116-136, enacted on March 27, Start Printed Page 521372020, to expand Covered Countermeasures under the PREP Act. On January 31, 2020, the Secretary declared a public health emergency pursuant to section 319 of the PHS Act, 42 U.S.C.

247d, effective January 27, 2020, for the entire United States to aid in the response of the nation's health care community to the hypertension medications outbreak. Pursuant to section 319 of the PHS Act, the Secretary renewed that declaration on April 26, 2020, and July 25, 2020. On March 10, 2020, the Secretary issued a Declaration under the PREP Act for medical countermeasures against hypertension medications (85 FR 15198, Mar. 17, 2020) (the Declaration).

On April 10, the Secretary amended the Declaration under the PREP Act to extend liability immunity to covered countermeasures authorized under the CARES Act (85 FR 21012, Apr. 15, 2020). On June 4, the Secretary amended the Declaration to clarify that covered countermeasures under the Declaration include qualified countermeasures that limit the harm hypertension medications might otherwise cause. The Secretary now amends section V of the Declaration to identify as qualified persons covered under the PREP Act, and thus authorizes, certain State-licensed pharmacists to order and administer, and pharmacy interns (who are licensed or registered by their State board of pharmacy and acting under the supervision of a State-licensed pharmacist) to administer, any treatment that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule (ACIP-recommended treatments).[] The Secretary also amends section VIII of the Declaration to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures includes not only hypertension medications caused by hypertension or a lasix mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by hypertension medications, hypertension, or a lasix mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Description of This Amendment by Section Section V. Covered Persons Under the PREP Act and the Declaration, a “qualified person” is a “covered person.” Subject to certain limitations, a covered person is immune from suit and liability under Federal and State law with respect to all claims for loss caused by, arising out of, relating to, or resulting from the administration or use of a covered countermeasure if a declaration under subsection (b) has been issued with respect to such countermeasure. €œQualified person” includes (A) a licensed health professional or other individual who is authorized to prescribe, administer, or dispense such countermeasures under the law of the State in which the countermeasure was prescribed, administered, or dispensed. Or (B) “a person within a category of persons so identified in a declaration by the Secretary” under subsection (b) of the PREP Act.

42 U.S.C. 247d-6d(i)(8).[] By this amendment to the Declaration, the Secretary identifies an additional category of persons who are qualified persons under section 247d-6d(i)(8)(B).[] On May 8, 2020, CDC reported, “The identified declines in routine pediatric treatment ordering and doses administered might indicate that U.S. Children and their communities face increased risks for outbreaks of treatment-preventable diseases,” and suggested that a decrease in rates of routine childhood vaccinations were due to changes in healthcare access, social distancing, and other hypertension medications mitigation strategies.[] The report also stated that “[p]arental concerns about potentially exposing their children to hypertension medications during well child visits might contribute to the declines observed.” [] On July 10, 2020, CDC reported its findings of a May survey it conducted to assess the capacity of pediatric health care practices to provide immunization services to children during the hypertension medications lasix. The survey, which was limited to practices participating in the treatments for Children program, found that, as of mid-May, 15 percent of Northeast pediatric practices were closed, 12.5 percent of Midwest practices were closed, 6.2 percent of practices in the South were closed, and 10 percent of practices in the West were closed.

Most practices had reduced office hours for in-person visits. When asked whether their practices would likely be able to accommodate new patients for immunization services through August, 418 practices (21.3 percent) either responded that this was not likely or the practice was permanently closed or not resuming immunization services for all patients, and 380 (19.6 percent) responded that they were unsure. Urban practices and those in the Northeast were less likely to be able to accommodate new patients compared with rural practices and those in the South, Midwest, or West.[] In response to these troubling developments, CDC and the American Academy of Pediatrics have stressed, “Well-child visits and vaccinations are essential services and help make sure children are protected.” [] The Secretary re-emphasizes that important recommendation to parents and legal guardians here. If your child is due for a well-child visit, contact your pediatrician's or other primary-care provider's office and ask about ways that the office safely offers well-child visits and vaccinations.

Many medical offices are taking extra steps to make sure that well-child visits can occur safely during the hypertension medications lasix, including. Scheduling sick visits and well-child visits during different times of the Start Printed Page 52138day or days of the week, or at different locations. Asking patients to remain outside until it is time for their appointments to reduce the number of people in waiting rooms. Adhering to recommended social (physical) distancing and other -control practices, such as the use of masks.

The decrease in childhood-vaccination rates is a public health threat and a collateral harm caused by hypertension medications. Together, the United States must turn to available medical professionals to limit the harm and public health threats that may result from decreased immunization rates. We must quickly do so to avoid preventable s in children, additional strains on our healthcare system, and any further increase in avoidable adverse health consequences—particularly if such complications coincide with additional resurgence of hypertension medications. Together with pediatricians and other healthcare professionals, pharmacists are positioned to expand access to childhood vaccinations.

Many States already allow pharmacists to administer treatments to children of any age.[] Other States permit pharmacists to administer treatments to children depending on the age—for example, 2, 3, 5, 6, 7, 9, 10, 11, or 12 years of age and older.[] Few States restrict pharmacist-administered vaccinations to only adults.[] Many States also allow properly trained individuals under the supervision of a trained pharmacist to administer those treatments.[] Pharmacists are well positioned to increase access to vaccinations, particularly in certain areas or for certain populations that have too few pediatricians and other primary-care providers, or that are otherwise medically underserved.[] As of 2018, nearly 90 percent of Americans lived within five miles of a community pharmacy.[] Pharmacies often offer extended hours and added convenience. What is more, pharmacists are trusted healthcare professionals with established relationships with their patients. Pharmacists also have strong relationships with local medical providers and hospitals to refer patients as appropriate. For example, pharmacists already play a significant role in annual influenza vaccination.

In the early 2018-19 season, they administered the influenza treatment to nearly a third of all adults who received the treatment.[] Given the potential danger of serious influenza and continuing hypertension medications outbreaks this autumn and the impact that such concurrent outbreaks may have on our population, our healthcare system, and our whole-of-nation response to the hypertension medications lasix, we must quickly expand access to influenza vaccinations. Allowing more qualified pharmacists to administer the influenza treatment to children will make vaccinations more accessible. Therefore, the Secretary amends the Declaration to identify State-licensed pharmacists (and pharmacy interns acting under their supervision if the pharmacy intern is licensed or registered by his or her State board of pharmacy) as qualified persons under section 247d-6d(i)(8)(B) when the pharmacist orders and either the pharmacist or the supervised pharmacy intern administers treatments to individuals ages three through 18 pursuant to the following requirements. The treatment must be FDA-authorized or FDA-approved.

The vaccination must be ordered and administered according to ACIP's standard immunization schedule.[] The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training Start Printed Page 52139program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.[] The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation.[] The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.[] The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment.[] The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregivers accompanying the children of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate.[] These requirements are consistent with those in many States that permit licensed pharmacists to order and administer treatments to children and permit licensed or registered pharmacy interns acting under their supervision to administer treatments to children.[] Administering vaccinations to children age three and older is less complicated and requires less training and resources than administering vaccinations to younger children. That is because ACIP generally recommends administering intramuscular injections in the deltoid muscle for individuals age three and older.[] For individuals less than three years of age, ACIP generally recommends administering intramuscular injections in the anterolateral aspect of the thigh muscle.[] Administering injections in the thigh muscle often presents additional complexities and requires additional training and resources including additional personnel to safely position the child while another healthcare professional injects the treatment.[] Moreover, as of 2018, 40% of three-year-olds were enrolled in preprimary programs (i.e.

Preschool or kindergarten programs).[] Preprimary programs are beginning in the coming weeks or months, so the Secretary has concluded that it is particularly important for individuals ages three through 18 to receive ACIP-recommended treatments according to ACIP's standard immunization schedule. All States require children to be vaccinated against certain communicable diseases as a condition of school attendance. These laws often apply to both public and private schools with identical immunization and exemption provisions.[] As nurseries, preschools, kindergartens, and schools reopen, increased access to childhood vaccinations is essential to ensuring children can return. Notwithstanding any State or local scope-of-practice legal requirements, (1) qualified licensed pharmacists are identified as qualified persons to order and administer ACIP-recommended treatments and (2) qualified State-licensed or registered pharmacy interns are identified as qualified persons to administer the ACIP-recommended treatments ordered by their supervising qualified licensed pharmacist.[] Both the PREP Act and the June 4, 2020 Second Amendment to the Declaration define “covered countermeasures” to include qualified lasix and epidemic products that “limit the harm such lasix or epidemic might otherwise cause.” [] The troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by Start Printed Page 52140hypertension medications as set forth in Sections VI and VIII of this Declaration.[] Hence, such vaccinations are “covered countermeasures” under the PREP Act and the June 4, 2020 Second Amendment to the Declaration.

Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program. Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C. 300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program.

All other terms and conditions of the Declaration apply to such covered countermeasures. Section VIII. Category of Disease, Health Condition, or Threat As discussed, the troubling decrease in ACIP-recommended childhood vaccinations and the resulting increased risk of associated diseases, adverse health conditions, and other threats are categories of harms otherwise caused by hypertension medications. The Secretary therefore amends section VIII, which describes the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures, to clarify that the category of disease, health condition, or threat for which he recommends the administration or use of the Covered Countermeasures is not only hypertension medications caused by hypertension or a lasix mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by hypertension medications, hypertension, or a lasix mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Amendments to Declaration Amended Declaration for Public Readiness and Emergency Preparedness Act Coverage for medical countermeasures against hypertension medications. Sections V and VIII of the March 10, 2020 Declaration under the PREP Act for medical countermeasures against hypertension medications, as amended April 10, 2020 and June 4, 2020, are further amended pursuant to section 319F-3(b)(4) of the PHS Act as described below. All other sections of the Declaration remain in effect as published at 85 FR 15198 (Mar. 17, 2020) and amended at 85 FR 21012 (Apr.

15, 2020) and 85 FR 35100 (June 8, 2020). 1. Covered Persons, section V, delete in full and replace with. V.

Covered Persons 42 U.S.C. 247d-6d(i)(2), (3), (4), (6), (8)(A) and (B) Covered Persons who are afforded liability immunity under this Declaration are “manufacturers,” “distributors,” “program planners,” “qualified persons,” and their officials, agents, and employees, as those terms are defined in the PREP Act, and the United States. In addition, I have determined that the following additional persons are qualified persons. (a) Any person authorized in accordance with the public health and medical emergency response of the Authority Having Jurisdiction, as described in Section VII below, to prescribe, administer, deliver, distribute or dispense the Covered Countermeasures, and their officials, agents, employees, contractors and volunteers, following a Declaration of an emergency.

(b) any person authorized to prescribe, administer, or dispense the Covered Countermeasures or who is otherwise authorized to perform an activity under an Emergency Use Authorization in accordance with Section 564 of the FD&C Act. (c) any person authorized to prescribe, administer, or dispense Covered Countermeasures in accordance with Section 564A of the FD&C Act. And (d) a State-licensed pharmacist who orders and administers, and pharmacy interns who administer (if the pharmacy intern acts under the supervision of such pharmacist and the pharmacy intern is licensed or registered by his or her State board of pharmacy), treatments that the Advisory Committee on Immunization Practices (ACIP) recommends to persons ages three through 18 according to ACIP's standard immunization schedule. Such State-licensed pharmacists and the State-licensed or registered interns under their supervision are qualified persons only if the following requirements are met.

The treatment must be FDA-authorized or FDA-approved. The vaccination must be ordered and administered according to ACIP's standard immunization schedule. The licensed pharmacist must complete a practical training program of at least 20 hours that is approved by the Accreditation Council for Pharmacy Education (ACPE). This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments.

The licensed or registered pharmacy intern must complete a practical training program that is approved by the ACPE. This training program must include hands-on injection technique, clinical evaluation of indications and contraindications of treatments, and the recognition and treatment of emergency reactions to treatments. The licensed pharmacist and licensed or registered pharmacy intern must have a current certificate in basic cardiopulmonary resuscitation. The licensed pharmacist must complete a minimum of two hours of ACPE-approved, immunization-related continuing pharmacy education during each State licensing period.

The licensed pharmacist must comply with recordkeeping and reporting requirements of the jurisdiction in which he or she administers treatments, including informing the patient's primary-care provider when available, submitting the required immunization information to the State or local immunization information system (treatment registry), complying with requirements with respect to reporting adverse events, and complying with requirements whereby the person administering a treatment must review the treatment registry or other vaccination records prior to administering a treatment. The licensed pharmacist must inform his or her childhood-vaccination patients and the adult caregiver accompanying the child of the importance of a well-child visit with a pediatrician or other licensed primary-care provider and refer patients as appropriate. Nothing in this Declaration shall be construed to affect the National treatment Injury Compensation Program, including an injured party's ability to obtain compensation under that program. Covered countermeasures that are subject to the National treatment Injury Compensation Program authorized under 42 U.S.C.

300aa-10 et seq. Are covered under this Declaration for the purposes of liability immunity and injury compensation only to the extent that injury compensation is not provided under that Program. All other Start Printed Page 52141terms and conditions of the Declaration apply to such covered countermeasures. 2.

Category of Disease, Health Condition, or Threat, section VIII, delete in full and replace with. VIII. Category of Disease, Health Condition, or Threat 42 U.S.C. 247d-6d(b)(2)(A) The category of disease, health condition, or threat for which I recommend the administration or use of the Covered Countermeasures is not only hypertension medications caused by hypertension or a lasix mutating therefrom, but also other diseases, health conditions, or threats that may have been caused by hypertension medications, hypertension, or a lasix mutating therefrom, including the decrease in the rate of childhood immunizations, which will lead to an increase in the rate of infectious diseases.

Start Authority 42 U.S.C. 247d-6d. End Authority Start Signature Dated. August 19, 2020.

Alex M. Azar II, Secretary of Health and Human Services. End Signature End Supplemental Information [FR Doc. 2020-18542 Filed 8-20-20.

4:15 pm]BILLING CODE 4150-03-PToday, the U.S. Department of Health and Human Services released Healthy People 2030, the nation's 10-year plan for addressing our most critical public health priorities and challenges. Since 1980, HHS's Office of Disease Prevention and Health Promotion has set measurable objectives and targets to improve the health and well-being of the nation.This decade, Healthy People 2030 features 355 core – or measurable – objectives with 10-year targets, new objectives related to opioid use disorder and youth e-cigarette use, and resources for adapting Healthy People 2030 to emerging public health threats like hypertension medications. For the first time, Healthy People 2030 also sets 10-year targets for objectives related to social determinants of health."Healthy People was the first national effort to lay out a set of data-driven priorities for health improvement," said HHS Secretary Alex Azar.

"Healthy People 2030 adopts a more focused set of objectives and more rigorous data standards to help the federal government and all of our partners deliver results on these important goals over the next decade."Healthy People has led the nation with its focus on social determinants of health, and continues to prioritize economic stability, education access and quality, health care access and quality, neighborhood and built environment, and social and community context as factors that influence health. Healthy People 2030 also continues to prioritize health disparities, health equity, and health literacy."Now more than ever, we need programs like Healthy People that set a shared vision for a healthier nation, where all people can achieve their full potential for health and well-being across the lifespan," said ADM Brett P. Giroir, MD, Assistant Secretary for Health. "hypertension medications has brought the importance of public health to the forefront of our national dialogue.

Achieving Healthy People 2030's vision would help the United States become more resilient to public health threats like hypertension medications."Healthy People 2030 emphasizes collaboration, with objectives and targets that span multiple sectors. A federal advisory committee of 13 external thought leaders and a workgroup of subject matter experts from more than 20 federal agencies contributed to Healthy People 2030, along with public comments received throughout the development process.The HHS Office of Disease Prevention and Health Promotion leads Healthy People in partnership with the National Center for Health Statistics at the Centers for Disease Control and Prevention, which oversees data in support of the initiative.HHS Secretary Alex M. Azar II, ADM Brett P. Giroir, MD, Assistant Secretary for Health, and U.S.

Surgeon General Jerome M. Adams, MD, MPH, and others from HHS and CDC will launch Healthy People 2030 during a webcast on August 18 at 1 pm (EDT) at https://www.hhs.gov/live. No registration is necessary. For more information about Healthy People 2030, visit https://healthypeople.gov..

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The actions needed at country level, the challenges lasix drug interactions faced and the support required from regional and global partners.DATE. SEPTEMBER 3 2020TIME. 14:00 - lasix drug interactions 16:00 CETRegister in advance.

Click here to register.WHO has been made aware of multiple, recent reports of eye injury, including blindness, with the lasix drug interactions use of chlorhexidine gluconate 7.1%, in nine countries in sub Saharan Africa.Chlorhexidine gluconate (CHX), available as an aqueous solution or as a gel (delivering 4% chlorhexidine), is used in umbilical cord care, and is listed in the WHO Essential Medicines List1. WHO recommends daily chlorhexidine (4%) application to the umbilical home cord stump during the first week of life for newborns who are born at home in settings with high neonatal mortality (neonatal mortality rate >30 per 1000). Clean, dry cord care is recommended for newborns born lasix drug interactions in health facilities, and at home in low neonatal mortality settings.

Use of chlorhexidine in these situations may be considered only to replace application of a harmful traditional substance such as cow dung to the cord stump. The use of CHX is being implemented in many countries (South Asia and sub-Saharan Africa) as part of a package of essential newborn interventions to reduce lasix drug interactions the incidence of omphalitis2.CHX causes serious harm if mistakenly applied to the eyes, resulting in severe eye injuries. Over forty (40) cases of such incorrect administration are recorded, either as media reports, lasix drug interactions or in the literature, since 2015.

Injuries associated with both the liquid and gel (ointment) formulations have been reported when CHX was mistaken for eye drops or ointments.The present Alert is being issued to warn all stakeholders involved in the umbilical cord care programmes about this potential misadministration and risk of serious injury with CHX. All healthcare professionals, caregivers and others involved in its distribution, use and/or administration are advised to take all necessary measures and precautions to ensure its correct use and administration.Suggestions to National Neonatal and Reproductive Health Programmes and/or Regulators include the following:Assess what products are part of the newborn package and select the optimal primary container/dosage form for CHX or modify the design of the container to distinguish the product lasix drug interactions from other medicines typically used for newborns.Update the product label with appropriate information on the safe use of the product.Develop more detailed instructions for users (flyers, posters, pictorials etc.) that are culturally appropriate and easy to understand, to ensure correct use of the product.Train health care professionals who interact with mothers and/or provide the product to ensure the full understanding of the indications and contraindications for use and application methods.All stakeholders are advised to remain alert to incidents of eye injury with CHX in their settings and to report these to their National Regulatory Authority (NRA). Member States are reminded that adverse events associated with the use of any medicinal product should be reported to the National Regulatory Authority.For any questions relating to this alert please contact Dr S Pal (pals@who.int) or Dr J Simon (simonjo@who.int).FOOTNOTE:.

Moving faster to end preventable newborn deaths and stillbirths by lasix prices walmart 2030Global actions now will determine the course of maternal and newborn health for the next decade and the health and lives of future generations. Essential health services, including high-quality maternal and newborn health care must be sustained and further strengthened to withstand shocks like hypertension medications, in order to protect lasix prices walmart the lives and health of women and children and make progress towards the SDGs. Countries and partners will discuss how to meet these targets and milestones. The actions needed at country level, the challenges faced and the support required from lasix prices walmart regional and global partners.DATE. SEPTEMBER 3 2020TIME.

14:00 - 16:00 lasix prices walmart CETRegister in advance. Click here to register.WHO has been made aware of multiple, recent reports of eye injury, including blindness, lasix prices walmart with the use of chlorhexidine gluconate 7.1%, in nine countries in sub Saharan Africa.Chlorhexidine gluconate (CHX), available as an aqueous solution or as a gel (delivering 4% chlorhexidine), is used in umbilical cord care, and is listed in the WHO Essential Medicines List1. WHO recommends daily chlorhexidine (4%) application to the umbilical cord stump during the first week of life for newborns who are born at home in settings with high neonatal mortality (neonatal mortality rate >30 per 1000). Clean, dry cord care is recommended for newborns lasix prices walmart born in health facilities, and at home in low neonatal mortality settings. Use of chlorhexidine in these situations may be considered only to replace application of a harmful traditional substance such as cow dung to the cord stump.

The use of CHX is being implemented in many countries (South Asia and sub-Saharan lasix prices walmart Africa) as part of a package of essential newborn interventions to reduce the incidence of omphalitis2.CHX causes serious harm if mistakenly applied to the eyes, resulting in severe eye injuries. Over forty (40) cases of such incorrect administration are recorded, either lasix prices walmart as media reports, or in the literature, since 2015. Injuries associated with both the liquid and gel (ointment) formulations have been reported when CHX was mistaken for eye drops or ointments.The present Alert is being issued to warn all stakeholders involved in the umbilical cord care programmes about this potential misadministration and risk of serious injury with CHX. All healthcare professionals, caregivers and others involved in its distribution, use and/or administration are advised to take all necessary measures and precautions to ensure its correct use and administration.Suggestions to National Neonatal and Reproductive Health Programmes and/or Regulators include the following:Assess what products are part of the newborn package and select the optimal primary container/dosage form for CHX or modify the design of the container to distinguish the product from other medicines typically used for newborns.Update the product label with appropriate information on the safe use of the product.Develop more detailed instructions for users (flyers, posters, pictorials etc.) that are culturally appropriate and easy to understand, to ensure correct use of the product.Train health care professionals who interact with mothers and/or provide the product to ensure the full understanding of the indications and contraindications for use and application methods.All stakeholders are advised to remain alert to incidents of eye injury with CHX in their settings and to report these to their National lasix prices walmart Regulatory Authority (NRA). Member States are reminded that adverse events associated with the use of any medicinal product should be reported to the National Regulatory Authority.For any questions relating to this alert please contact Dr S Pal (pals@who.int) or Dr J Simon (simonjo@who.int).FOOTNOTE:.

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Today we know that the universe my company is far bigger and stranger buy lasix online canada than anyone suspected. Not only does it extend beyond the Milky Way to untold numbers of other galaxies—this would come as a surprise to astronomers of the 19th and early 20th century to whom our galaxy was “the universe”—but it is expanding faster every day. Now we can confidently trace cosmic history back 13.8 billion years to a moment only a billionth of a second after the big bang. Astronomers have pinned down our universe's expansion rate, the mean density of its main constituents, and other key numbers to a precision of 1 or buy lasix online canada 2 percent. They have also worked out new laws of physics governing space—general relativity and quantum mechanics—that turn out to be much more outlandish than the classical laws people understood before.

These laws in turn predicted cosmic oddities such as black holes, neutron stars and gravitational waves. The story of how we gained this knowledge is full of buy lasix online canada accidental discoveries, stunning surprises and dogged scientists pursuing goals others thought unreachable. Our first hint of the true nature of stars came in 1860, when Gustav Kirchhoff recognized that the dark lines in the spectrum of light coming from the sun were caused by different elements absorbing specific wavelengths. Astronomers analyzed similar features in the light of other bright stars and discovered that they were made of the same materials found on Earth—not of some mysterious “fifth essence” as the ancients had believed. But it took longer to understand what fuel made buy lasix online canada the stars shine.

Lord Kelvin (William Thomson) calculated that if stars derived their power just from gravity, slowly deflating as their radiation leaked out, then the sun's age was 20 million to 40 million years—far less time than Charles Darwin or the geologists of the time inferred had elapsed on Earth. In his last paper on the subject, in 1908, Kelvin inserted an escape clause stating that he would stick by his estimate “unless there were some other energy source laid up in the storehouse of creation.” That source, it turned out, is nuclear fusion—the process by which atomic nuclei join to create a larger nucleus and release energy. In 1925 astrophysicist Cecilia Payne-Gaposchkin used the light spectra of stars to calculate their chemical buy lasix online canada abundances and found that, unlike Earth, they were made mainly of hydrogen and helium. She revealed her conclusions in what astronomer Otto Struve described as “the most brilliant Ph.D. Thesis ever written in astronomy.” A decade later physicist Hans Bethe showed that the fusion of hydrogen nuclei into helium was the main power source in ordinary stars.

What is buy lasix online canada the source of the sun's power?. The answer—fusion—came in 1938. Credit. SOHO (ESA and NASA) At the same time stars were becoming less mysterious, buy lasix online canada so, too, was the nature of fuzzy “nebulae” becoming clearer. In a “great debate” held before the National Academy of Sciences in Washington, D.C., on April 26, 1920, Harlow Shapley maintained that our Milky Way was preeminent and that all the nebulae were part of it.

In contrast, Heber Curtis argued that some of the fuzzy objects in the sky were separate galaxies—“island universes”—fully the equal of our Milky Way. The conflict was settled buy lasix online canada not that night but just a few years later, in 1924, when Edwin Hubble measured the distances to many nebulae and proved they were beyond the reaches of the Milky Way. His evidence came from Cepheids, variable stars in the nebulae that reveal their true brightness, and thus their distance, by their pulsation period—a relation discovered by Henrietta Swan Leavitt. Soon after Hubble realized that the universe was bigger than many had thought, he found that it was still growing. In 1929 he discovered that spectral features in buy lasix online canada the starlight from distant galaxies appeared redder—that is, they had longer wavelengths—than the same features in nearby stars.

If this effect was interpreted as a Doppler shift—the natural spreading of waves as they recede—it would imply that other galaxies were moving away from one another and from us. Indeed, the farther away they were, the faster their recession seemed to be. This was the first clue that our cosmos was not static but was expanding all the buy lasix online canada time. The universe also appeared to contain much that we could not see. In 1933 Fritz Zwicky estimated the mass of all the stars in the Coma cluster of galaxies and found that they make up only about 1 percent of the mass necessary to keep the cluster from flying apart.

The discrepancy was dubbed “the missing mass problem,” but many scientists at the time doubted Zwicky's suggestion that hidden matter might be to blame buy lasix online canada. The question remained divisive until the 1970s, when work by Vera Rubin and W. Kent Ford (observing stars) and by Morton Roberts and Robert Whitehurst (making radio observations) showed that the outer parts of galactic disks would also fly apart unless they were subject to a stronger gravitational pull than stars and gas alone could provide. Finally, most astronomers were compelled to accept that some kind buy lasix online canada of “dark matter” must be present. €œWe have peered into a new world,” Rubin wrote, “and have seen that it is more mysterious and more complex than we had imagined.” Scientists now believe that dark matter outnumbers visible matter by about a factor of five, yet we are hardly closer than we were in the 1930s to figuring out what it is.

Gravity, the force that revealed all that dark matter, has proved to be nearly as baffling. A pivotal moment came in 1915 when Albert Einstein published his general theory of relativity, which transcended Isaac Newton's mechanics buy lasix online canada and revealed that gravity is actually the deformation of the fabric of space and time. This new theory was slow to take hold. Even after it was shown to be correct by observations of a 1919 solar eclipse, many dismissed the theory as an interesting quirk—after all, Newton's laws were still good enough for calculating most things. €œThe discoveries, while very important, did not, however, affect anything on this buy lasix online canada earth,” astronomer W.J.S.

Lockyer told the New York Times after the eclipse. For almost half a century after it was proposed, general relativity was sidelined from the mainstream of physics. Then, beginning in the 1960s, astronomers started discovering new and extreme phenomena that buy lasix online canada only Einstein's ideas could explain. One example lurks in the Crab Nebula, one of the best-known objects in the sky, which is composed of the expanding debris from a supernova witnessed by Chinese astronomers in a.d. 1054.

Since it appeared, buy lasix online canada the nebula has kept on shining blue and bright—but how?. Its light source was a longtime puzzle, but the answer came in 1968, when the dim star at its center was revealed to be anything but normal. It was actually an ultracompact neutron star, heavier than the sun but only a few miles in radius and spinning at 30 revolutions per second. €œThis was a totally unexpected, totally new kind of object behaving in a way that astronomers had never expected, never dreamt of,” said Jocelyn Bell Burnell, one of the discoverers buy lasix online canada of the phenomenon. The star's excessive spin sends out a wind of fast electrons that generate the blue light.

The gravitational force at the surface of such an incredibly dense object falls way outside of Newton's purview—a rocket would need to be fired at half the speed of light to escape its pull. Here the relativistic buy lasix online canada effects predicted by Einstein must be taken into account. Thousands of such spinning neutron stars—called pulsars—have been discovered. All are believed to be remnants of the cores of stars that exploded as supernovae, offering an ideal laboratory for studying the laws of nature under extreme conditions. The most exotic result of Einstein's theory was the concept of black holes—objects that have collapsed so far that not even light can buy lasix online canada escape their gravitational pull.

For decades these were only conjecture, and Einstein wrote in 1939 that they “do not exist in physical reality.” But in 1963 astronomers discovered quasars. Mysterious, hyperluminous beacons in the centers of some galaxies. More than a decade passed before a consensus emerged that this buy lasix online canada intense brightness was generated by gas swirling into huge black holes lurking in the galaxies' cores. It was the strongest evidence yet that these bizarre predictions of general relativity actually exist. When did the universe begin?.

Did it even have a buy lasix online canada beginning?. Astronomers had long debated these questions when, in the middle of the 20th century, two competing theories proposed very different answers. The “hot big bang” model said the cosmos began extremely small, hot and dense and then cooled and spread out over time. The “steady state” hypothesis held that the universe had essentially buy lasix online canada existed in the same form forever. The contest was settled by a serendipitous discovery.

In 1965 radio astronomers Arno Penzias and Robert Wilson were trying to calibrate a new antenna at Bell Labs in New Jersey. They had a buy lasix online canada problem. No matter what they did to reduce background interference, they measured a consistent level of noise in every direction. They even evicted a family of pigeons that had been nesting in the antenna in the hope that they were the source of the problem. But the signal persisted buy lasix online canada.

They had discovered that intergalactic space is not completely cold. Instead it is warmed to nearly three kelvins (just above absolute zero) by weak microwaves. Penzias and Wilson had accidentally buy lasix online canada uncovered the “afterglow of creation”—the cooled and diluted relic of an era when everything in the universe was squeezed until it was hot and dense. The finding tipped the balance firmly in favor of the big bang picture of cosmology. According to the model, during the earliest, hottest epochs of time, the universe was opaque, rather like the inside of a star, and light was repeatedly scattered by electrons.

When the buy lasix online canada temperature fell to 3,000 kelvins, however, the electrons slowed down enough to be captured by protons and created neutral atoms. Thereafter light could travel freely. The Bell Labs signal was this ancient light, first released about 300,000 years after the birth of the universe and still pervading the cosmos—what we call the cosmic microwave background. It took a while for the magnitude of the discovery to sink buy lasix online canada in for the scientists who made it. €œWe were very pleased to have a possible explanation [for the antenna noise], but I don't think either of us really took the cosmology very seriously at first,” Wilson says.

€œWalter Sullivan wrote a first-page article in the New York Times about it, and I began to think at that point that, you know, maybe I better start taking this cosmology seriously.” Measurements of this radiation have since enabled scientists to understand how galaxies emerged. Precise observations of the buy lasix online canada microwaves reveal that they are not completely uniform over the sky. Some patches are slightly hotter, others slightly cooler. The amplitude of these fluctuations is only one part in 100,000, but they are the seeds of today's cosmic structure. Any region of the expanding universe that started buy lasix online canada off slightly denser than average expanded less because it was subjected to extra gravity.

Its growth lagged further and further, the contrast between its density and that of its surroundings becoming greater and greater. Eventually these clumps were dense enough that gas was pulled in and compressed into stars, forming galaxies. The crucial buy lasix online canada point is this. Computer models that simulate this process are fed the initial fluctuations measured in the cosmic microwave background, which represent the universe when it was 300,000 years old. The output after 13.8 billion years of virtual time have elapsed is a cosmos where galaxies resemble those we see, clustered as they are in the actual universe.

This is a real buy lasix online canada triumph. We understand, at least in outline, 99.998 percent of cosmic history. It is not only the big cosmic picture that we have come to understand. A series of discoveries has also revealed the history of the elemental building blocks that make up stars, planets and even our own bodies. Starting in the 1950s, buy lasix online canada progress in atomic physics led to accurate modeling of stars' surface layers.

Simultaneously, detailed knowledge of the nuclei not just of hydrogen and helium atoms but also of the rest of the elements allowed scientists to calculate which nuclear reactions dominate at different stages in a star's life. Astronomers came to understand how nuclear fusion creates an onion-skin structure in massive stars as atoms successively fuse to build heavier and heavier elements, ending with iron in the innermost, hottest layer. Inside the buy lasix online canada Crab Nebula is a neutron star. Classical physics fails, and relativity applies. Credit.

NASA, ESA and Hubble Heritage Team (STSCI and buy lasix online canada AURA) Astronomers also learned how stars die when they exhaust their hydrogen fuel and blow off their outer gaseous layers. Lighter stars then settle down to a quiet demise as dense, dim objects called white dwarfs, but heavier stars shed more of their mass, either in winds during their lives or in an explosive death via supernova. This expelled mass turns out to be crucial to our own existence. It mixes into the interstellar medium and recondenses into buy lasix online canada new stars orbited by planets such as Earth. The concept was conceived by Fred Hoyle, who developed it during the 1950s along with two other British astronomers, Margaret Burbidge and Geoffrey Burbidge, and American nuclear physicist William Fowler.

In their classic 1957 paper in Reviews of Modern Physics (known by the initials of its authors as BBFH), they analyzed the networks of the nuclear reactions involved and discovered how most atoms in the periodic table came to exist. They calculated why oxygen and carbon, for instance, are common, whereas buy lasix online canada gold and uranium are rare. Our galaxy, it turns out, is a huge ecological system where gas is being recycled through successive generations of stars. Each of us contains atoms forged in dozens of different stars spread across the Milky Way that lived and died more than 4.5 billion years ago. Scientists long assumed this process buy lasix online canada was seeding planets—and possibly even life—around stars other than our own sun.

But we did not know for sure whether planets existed outside our solar system until the 1990s, when astronomers developed clever methods for identifying worlds that are too dim for us to see directly. One technique looks for tiny periodic changes in a star's movement caused by the gravitational pull of a planet orbiting it. In 1995 Michel Mayor and Didier Queloz used this strategy to buy lasix online canada detect 51 Pegasi b, the first known exoplanet orbiting a sunlike star. The technique can reveal a planet's mass, the length of its “year” and the shape of its orbit. So far more than 800 exoplanets have been found this way.

A second buy lasix online canada technique works better for smaller planets. A star dims slightly when a planet transits in front of it. An Earth-like planet passing a sunlike star can cause a dimming of about one part in 10,000 once per orbit. The Kepler buy lasix online canada spacecraft launched in 2009 found more than 2,000 planets this way, many no bigger than Earth. A big surprise to come from astronomers' success in planet hunting was the variety of different planets out there—many much larger and closer to their stars than the bodies in our solar system—suggesting that our cosmic neighborhood may be somewhat special.

By this point scientists understood where almost all the elements that form planets, stars and galaxies originated. The final piece in this buy lasix online canada puzzle, however, arrived very recently and from a seemingly unrelated inquiry. General relativity had predicted a phenomenon called gravitational waves—ripples in spacetime produced by the movement of massive objects. Despite decades of searching for them, however, no waves were seen—until September 2015. That was when the Laser Interferometer Gravitational-wave Observatory (LIGO) detected the first evidence of gravitational waves in the form of a “chirp”—a minute shaking of spacetime that speeds buy lasix online canada up and then dies away.

In this case, it was caused by two black holes in a binary system that had started out orbiting each other but gradually spiraled together and eventually converged into a single massive hole. The crash occurred more than a billion light-years away. LIGO's detectors consist of mirrors four kilometers apart whose separation is measured by laser beams that reflect light back buy lasix online canada and forth between them. A passing gravitational wave causes the space between the two mirrors to jitter by an amount millions of times as small as the diameter of a single atom—LIGO is indeed an amazing feat of precision engineering and perseverance. Since that first find, more than a dozen similar events have been detected, opening up a new field that probes the dynamics of space itself.

One event was of special astrophysical interest because it signaled the merger of two buy lasix online canada pulsars. Unlike black hole mergers, this kind of collision, a splat between two ultradense stars, yields a pulse of optical light, x-rays and gamma rays. The discovery filled a gap in the classic work of BBFH. The authors had explained the genesis of many of the elements in space but were flummoxed by the forging of gold buy lasix online canada. In the 1970s David N.

Schramm and his colleagues had speculated that the exotic nuclear processes involved in hypothetical mergers of pulsar stars might do the job—a theory that has since been validated. Despite the incredible progress in astronomy over the past 175 years, we have perhaps more questions now than we did back buy lasix online canada then. Take dark matter. I am on record as having said more than 20 years ago that we would know dark matter's nature long before today. Although that prediction has proved wrong, I have not given buy lasix online canada up hope.

Dark energy, however, is a different story. Dark energy entered the picture in 1998, when researchers measuring the distances and speeds of supernovae found that the expansion of the universe was actually accelerating. Gravitational attraction pulling galaxies toward one another buy lasix online canada seemed to be overwhelmed by a mysterious new force latent in empty space that pushes galaxies apart—a force that came to be known as dark energy. The mystery of dark energy has lingered—we still do not know what causes it or why it has the particular strength it does—and we probably will not understand it until we have a model for the graininess of space on a scale a billion billion times smaller than an atomic nucleus. Theorists working on string theory or loop quantum gravity are tackling this challenge, but the phenomenon seems so far from being accessible by any experiment that I am not expecting answers anytime soon.

The upside, however, is that a theory that could account for the energy in the vacuum of space might also yield insights into the very beginning of our universe, when everything was so compressed and buy lasix online canada dense that quantum fluctuations could shake the entire cosmos. Which brings us to another major question facing us now. How did it all begin?. What exactly buy lasix online canada set off the big bang that started our universe?. Did space undergo a period of extremely rapid early expansion called inflation, as many theorists believe?.

And there is something else. Some models, such as eternal inflation, suggest that “our” buy lasix online canada big bang could be just one island of spacetime in a vast archipelago—one big bang among many. If this hypothesis is true, different big bangs may cool down differently, leading to unique laws of physics in each case—a “multiverse” rather than a universe. Some physicists hate the multiverse concept because it means that we will never have neat explanations for the fundamental numbers that govern our physical laws, which may in this grander perspective be just environmental accidents. But our preferences are irrelevant buy lasix online canada to nature.

About 10 years ago I was on a panel at Stanford University where we were asked by someone in the audience how much we would bet on the multiverse concept. I said that on a scale of betting my goldfish, my dog or my life, I was nearly at the dog level. Andrei Linde, who had spent 25 years promoting eternal inflation, said he would almost buy lasix online canada bet his life. Later, on being told this, physicist Steven Weinberg said he would happily bet my dog and Linde's life. Linde, my dog and I will all be dead before the question is settled.

But none of this should be dismissed as metaphysics buy lasix online canada. It is speculative science—exciting science. And it may be true. And what will happen to buy lasix online canada this universe—or multiverse—of ours?. Long-range forecasts are seldom reliable, but the best and most conservative bet is that we have almost an eternity ahead with an ever colder and ever emptier cosmos.

Galaxies will accelerate away and disappear. All that will be left from our vantage point will be the remnants of the Milky Way, Andromeda and smaller buy lasix online canada neighbors. Protons may decay, dark matter particles may be annihilated, there may be occasional flashes when black holes evaporate—and then silence. This possible future is based on the assumption that the dark energy stays constant. If it buy lasix online canada decays, however, there could be a “big crunch” with the universe contracting in on itself.

Or if dark energy strengthens, there would be a “big rip” when galaxies, stars and even atoms are torn apart. Other questions closer to home tantalize us. Could there buy lasix online canada be life on any of these new planets we are discovering?. Here we are still in the realm of speculation. But unless the origin of life on Earth involved a rare fluke, I expect evidence of a biosphere on an exoplanet within 20 years.

I will not hold buy lasix online canada my breath for the discovery of aliens, but I think the search for extraterrestrial intelligence is a worthwhile gamble. Success in the search would carry the momentous message that concepts of logic and physics are not limited to the hardware in human skulls. Until now, progress in cosmology and astrophysics has owed 95 percent to advancing instruments and technology and less than 5 percent to armchair theory. I expect that buy lasix online canada balance to persist. What Hubble wrote in the 1930s remains a good maxim today.

€œNot until the empirical resources are exhausted, need we pass on to the dreamy realms of speculation.” There have been many particularly exhilarating eras in the past 175 years—the 1920s and 1930s, when we realized the universe was not limited to the Milky Way, and the 1960s and 1970s, when we discovered objects that defy classical physics, such as neutron stars and quasars, and clues about the beginning of time from the cosmic microwave background. Since then, the pace of advancement has crescendoed rather than slackened. When the history of science gets written, this amazing progress will be acclaimed as one of its greatest triumphs—up there with plate tectonics, the genome and the Standard Model of particle physics. And some major fields in astronomy are just getting going. Exoplanet research is only 25 years old, and serious work in astrobiology is really only starting.

Now we can confidently lasix prices walmart trace cosmic history back 13.8 billion years to a moment only a billionth of a second after the big bang. Astronomers have pinned down our universe's expansion rate, the mean density of its main constituents, and other key numbers to a precision of 1 or 2 percent. They have also worked out new laws of physics governing space—general relativity and quantum mechanics—that turn out to be much more outlandish than the classical laws people understood before. These laws lasix prices walmart in turn predicted cosmic oddities such as black holes, neutron stars and gravitational waves. The story of how we gained this knowledge is full of accidental discoveries, stunning surprises and dogged scientists pursuing goals others thought unreachable.

Our first hint of the true nature of stars came in 1860, when Gustav Kirchhoff recognized that the dark lines in the spectrum of light coming from the sun were caused by different elements absorbing specific wavelengths. Astronomers analyzed similar features in the light of other bright stars and discovered that they were made of the same materials found on Earth—not of some mysterious “fifth lasix prices walmart essence” as the ancients had believed. But it took longer to understand what fuel made the stars shine. Lord Kelvin (William Thomson) calculated that if stars derived their power just from gravity, slowly deflating as their radiation leaked out, then the sun's age was 20 million to 40 million years—far less time than Charles Darwin or the geologists of the time inferred had elapsed on Earth. In his last paper on the subject, in 1908, Kelvin inserted an escape clause stating that he would stick by his estimate “unless there were some other energy source laid up in the storehouse of creation.” That source, it turned out, is nuclear fusion—the process lasix prices walmart by which atomic nuclei join to create a larger nucleus and release energy.

In 1925 astrophysicist Cecilia Payne-Gaposchkin used the light spectra of stars to calculate their chemical abundances and found that, unlike Earth, they were made mainly of hydrogen and helium. She revealed her conclusions in what astronomer Otto Struve described as “the most brilliant Ph.D. Thesis ever written in astronomy.” A decade later physicist Hans Bethe showed that the fusion of hydrogen nuclei into helium lasix prices walmart was the main power source in ordinary stars. What is the source of the sun's power?. The answer—fusion—came in 1938.

Credit. SOHO (ESA and NASA) At the same time stars were becoming less mysterious, so, too, was the nature of fuzzy “nebulae” becoming clearer. In a “great debate” held before the National Academy of Sciences in Washington, D.C., on April 26, 1920, Harlow Shapley maintained that our Milky Way was preeminent and that all the nebulae were part of it. In contrast, Heber Curtis argued that some of the fuzzy objects in the sky were separate galaxies—“island universes”—fully the equal of our Milky Way. The conflict was settled not that night but just a few years later, in 1924, when Edwin Hubble measured the distances to many nebulae and proved they were beyond the reaches of the Milky Way.

His evidence came from Cepheids, variable stars in the nebulae that reveal their true brightness, and thus their distance, by their pulsation period—a relation discovered by Henrietta Swan Leavitt. Soon after Hubble realized that the universe was bigger than many had thought, he found that it was still growing. In 1929 he discovered that spectral features in the starlight from distant galaxies appeared redder—that is, they had longer wavelengths—than the same features in nearby stars. If this effect was interpreted as a Doppler shift—the natural spreading of waves as they recede—it would imply that other galaxies were moving away from one another and from us. Indeed, the farther away they were, the faster their recession seemed to be.

This was the first clue that our cosmos was not static but was expanding all the time. The universe also appeared to contain much that we could not see. In 1933 Fritz Zwicky estimated the mass of all the stars in the Coma cluster of galaxies and found that they make up only about 1 percent of the mass necessary to keep the cluster from flying apart. The discrepancy was dubbed “the missing mass problem,” but many scientists at the time doubted Zwicky's suggestion that hidden matter might be to blame. The question remained divisive until the 1970s, when work by Vera Rubin and W.

Kent Ford (observing stars) and by Morton Roberts and Robert Whitehurst (making radio observations) showed that the outer parts of galactic disks would also fly apart unless they were subject to a stronger gravitational pull than stars and gas alone could provide. Finally, most astronomers were compelled to accept that some kind of “dark matter” must be present. €œWe have peered into a new world,” Rubin wrote, “and have seen that it is more mysterious and more complex than we had imagined.” Scientists now believe that dark matter outnumbers visible matter by about a factor of five, yet we are hardly closer than we were in the 1930s to figuring out what it is. Gravity, the force that revealed all that dark matter, has proved to be nearly as baffling. A pivotal moment came in 1915 when Albert Einstein published his general theory of relativity, which transcended Isaac Newton's mechanics and revealed that gravity is actually the deformation of the fabric of space and time.

This new theory was slow to take hold. Even after it was shown to be correct by observations of a 1919 solar eclipse, many dismissed the theory as an interesting quirk—after all, Newton's laws were still good enough for calculating most things. €œThe discoveries, while very important, did not, however, affect anything on this earth,” astronomer W.J.S. Lockyer told the New York Times after the eclipse. For almost half a century after it was proposed, general relativity was sidelined from the mainstream of physics.

Then, beginning in the 1960s, astronomers started discovering new and extreme phenomena that only Einstein's ideas could explain. One example lurks in the Crab Nebula, one of the best-known objects in the sky, which is composed of the expanding debris from a supernova witnessed by Chinese astronomers in a.d. 1054. Since it appeared, the nebula has kept on shining blue and bright—but how?. Its light source was a longtime puzzle, but the answer came in 1968, when the dim star at its center was revealed to be anything but normal.

It was actually an ultracompact neutron star, heavier than the sun but only a few miles in radius and spinning at 30 revolutions per second. €œThis was a totally unexpected, totally new kind of object behaving in a way that astronomers had never expected, never dreamt of,” said Jocelyn Bell Burnell, one of the discoverers of the phenomenon. The star's excessive spin sends out a wind of fast electrons that generate the blue light. The gravitational force at the surface of such an incredibly dense object falls way outside of Newton's purview—a rocket would need to be fired at half the speed of light to escape its pull. Here the relativistic effects predicted by Einstein must be taken into account.

Thousands of such spinning neutron stars—called pulsars—have been discovered. All are believed to be remnants of the cores of stars that exploded as supernovae, offering an ideal laboratory for studying the laws of nature under extreme conditions. The most exotic result of Einstein's theory was the concept of black holes—objects that have collapsed so far that not even light can escape their gravitational pull. For decades these were only conjecture, and Einstein wrote in 1939 that they “do not exist in physical reality.” But in 1963 astronomers discovered quasars. Mysterious, hyperluminous beacons in the centers of some galaxies.

More than a decade passed before a consensus emerged that this intense brightness was generated by gas swirling into huge black holes lurking in the galaxies' cores. It was the strongest evidence yet that these bizarre predictions of general relativity actually exist. When did the universe begin?. Did it even have a beginning?. Astronomers had long debated these questions when, in the middle of the 20th century, two competing theories proposed very different answers.

The “hot big bang” model said the cosmos began extremely small, hot and dense and then cooled and spread out over time. The “steady state” hypothesis held that the universe had essentially existed in the same form forever. The contest was settled by a serendipitous discovery. In 1965 radio astronomers Arno Penzias and Robert Wilson were trying to calibrate a new antenna at Bell Labs in New Jersey. They had a problem.

No matter what they did to reduce background interference, they measured a consistent level of noise in every direction. They even evicted a family of pigeons that had been nesting in the antenna in the hope that they were the source of the problem. But the signal persisted. They had discovered that intergalactic space is not completely cold. Instead it is warmed to nearly three kelvins (just above absolute zero) by weak microwaves.

Penzias and Wilson had accidentally uncovered the “afterglow of creation”—the cooled and diluted relic of an era when everything in the universe was squeezed until it was hot and dense. The finding tipped the balance firmly in favor of the big bang picture of cosmology. According to the model, during the earliest, hottest epochs of time, the universe was opaque, rather like the inside of a star, and light was repeatedly scattered by electrons. When the temperature fell to 3,000 kelvins, however, the electrons slowed down enough to be captured by protons and created neutral atoms. Thereafter light could travel freely.

The Bell Labs signal was this ancient light, first released about 300,000 years after the birth of the universe and still pervading the cosmos—what we call the cosmic microwave background. It took a while for the magnitude of the discovery to sink in for the scientists who made it. €œWe were very pleased to have a possible explanation [for the antenna noise], but I don't think either of us really took the cosmology very seriously at first,” Wilson says. €œWalter Sullivan wrote a first-page article in the New York Times about it, and I began to think at that point that, you know, maybe I better start taking this cosmology seriously.” Measurements of this radiation have since enabled scientists to understand how galaxies emerged. Precise observations of the microwaves reveal that they are not completely uniform over the sky.

Some patches are slightly hotter, others slightly cooler. The amplitude of these fluctuations is only one part in 100,000, but they are the seeds of today's cosmic structure. Any region of the expanding universe that started off slightly denser than average expanded less because it was subjected to extra gravity. Its growth lagged further and further, the contrast between its density and that of its surroundings becoming greater and greater. Eventually these clumps were dense enough that gas was pulled in and compressed into stars, forming galaxies.

The crucial point is this. Computer models that simulate this process are fed the initial fluctuations measured in the cosmic microwave background, which represent the universe when it was 300,000 years old. The output after 13.8 billion years of virtual time have elapsed is a cosmos where galaxies resemble those we see, clustered as they are in the actual universe. This is a real triumph. We understand, at least in outline, 99.998 percent of cosmic history.

It is not only the big cosmic picture that we have come to understand. A series of discoveries has also revealed the history of the elemental building blocks that make up stars, planets and even our own bodies. Starting in the 1950s, progress in atomic physics led to accurate modeling of stars' surface layers. Simultaneously, detailed knowledge of the nuclei not just of hydrogen and helium atoms but also of the rest of the elements allowed scientists to calculate which nuclear reactions dominate at different stages in a star's life. Astronomers came to understand how nuclear fusion creates an onion-skin structure in massive stars as atoms successively fuse to build heavier and heavier elements, ending with iron in the innermost, hottest layer.

Inside the Crab Nebula is a neutron star. Classical physics fails, and relativity applies. Credit. NASA, ESA and Hubble Heritage Team (STSCI and AURA) Astronomers also learned how stars die when they exhaust their hydrogen fuel and blow off their outer gaseous layers. Lighter stars then settle down to a quiet demise as dense, dim objects called white dwarfs, but heavier stars shed more of their mass, either in winds during their lives or in an explosive death via supernova.

This expelled mass turns out to be crucial to our own existence. It mixes into the interstellar medium and recondenses into new stars orbited by planets such as Earth. The concept was conceived by Fred Hoyle, who developed it during the 1950s along with two other British astronomers, Margaret Burbidge and Geoffrey Burbidge, and American nuclear physicist William Fowler. In their classic 1957 paper in Reviews of Modern Physics (known by the initials of its authors as BBFH), they analyzed the networks of the nuclear reactions involved and discovered how most atoms in the periodic table came to exist. They calculated why oxygen and carbon, for instance, are common, whereas gold and uranium are rare.

Our galaxy, it turns out, is a huge ecological system where gas is being recycled through successive generations of stars. Each of us contains atoms forged in dozens of different stars spread across the Milky Way that lived and died more than 4.5 billion years ago. Scientists long assumed this process was seeding planets—and possibly even life—around stars other than our own sun. But we did not know for sure whether planets existed outside our solar system until the 1990s, when astronomers developed clever methods for identifying worlds that are too dim for us to see directly. One technique looks for tiny periodic changes in a star's movement caused by the gravitational pull of a planet orbiting it.

In 1995 Michel Mayor and Didier Queloz used this strategy to detect 51 Pegasi b, the first known exoplanet orbiting a sunlike star. The technique can reveal a planet's mass, the length of its “year” and the shape of its orbit. So far more than 800 exoplanets have been found this way. A second technique works better for smaller planets. A star dims slightly when a planet transits in front of it.

An Earth-like planet passing a sunlike star can cause a dimming of about one part in 10,000 once per orbit. The Kepler spacecraft launched in 2009 found more than 2,000 planets this way, many no bigger than Earth. A big surprise to come from astronomers' success in planet hunting was the variety of different planets out there—many much larger and closer to their stars than the bodies in our solar system—suggesting that our cosmic neighborhood may be somewhat special. By this point scientists understood where almost all the elements that form planets, stars and galaxies originated. The final piece in this puzzle, however, arrived very recently and from a seemingly unrelated inquiry.

General relativity had predicted a phenomenon called gravitational waves—ripples in spacetime produced by the movement of massive objects. Despite decades of searching for them, however, no waves were seen—until September 2015. That was when the Laser Interferometer Gravitational-wave Observatory (LIGO) detected the first evidence of gravitational waves in the form of a “chirp”—a minute shaking of spacetime that speeds up and then dies away. In this case, it was caused by two black holes in a binary system that had started out orbiting each other but gradually spiraled together and eventually converged into a single massive hole. The crash occurred more than a billion light-years away.

LIGO's detectors consist of mirrors four kilometers apart whose separation is measured by laser beams that reflect light back and forth between them. A passing gravitational wave causes the space between the two mirrors to jitter by an amount millions of times as small as the diameter of a single atom—LIGO is indeed an amazing feat of precision engineering and perseverance. Since that first find, more than a dozen similar events have been detected, opening up a new field that probes the dynamics of space itself. One event was of special astrophysical interest because it signaled the merger of two pulsars. Unlike black hole mergers, this kind of collision, a splat between two ultradense stars, yields a pulse of optical light, x-rays and gamma rays.

The discovery filled a gap in the classic work of BBFH. The authors had explained the genesis of many of the elements in space but were flummoxed by the forging of gold. In the 1970s David N. Schramm and his colleagues had speculated that the exotic nuclear processes involved in hypothetical mergers of pulsar stars might do the job—a theory that has since been validated. Despite the incredible progress in astronomy over the past 175 years, we have perhaps more questions now than we did back then.

Take dark matter. I am on record as having said more than 20 years ago that we would know dark matter's nature long before today. Although that prediction has proved wrong, I have not given up hope. Dark energy, however, is a different story. Dark energy entered the picture in 1998, when researchers measuring the distances and speeds of supernovae found that the expansion of the universe was actually accelerating.

Gravitational attraction pulling galaxies toward one another seemed to be overwhelmed by a mysterious new force latent in empty space that pushes galaxies apart—a force that came to be known as dark energy. The mystery of dark energy has lingered—we still do not know what causes it or why it has the particular strength it does—and we probably will not understand it until we have a model for the graininess of space on a scale a billion billion times smaller than an atomic nucleus. Theorists working on string theory or loop quantum gravity are tackling this challenge, but the phenomenon seems so far from being accessible by any experiment that I am not expecting answers anytime soon. The upside, however, is that a theory that could account for the energy in the vacuum of space might also yield insights into the very beginning of our universe, when everything was so compressed and dense that quantum fluctuations could shake the entire cosmos. Which brings us to another major question facing us now.

How did it all begin?. What exactly set off the big bang that started our universe?. Did space undergo a period of extremely rapid early expansion called inflation, as many theorists believe?. And there is something else. Some models, such as eternal inflation, suggest that “our” big bang could be just one island of spacetime in a vast archipelago—one big bang among many.

If this hypothesis is true, different big bangs may cool down differently, leading to unique laws of physics in each case—a “multiverse” rather than a universe. Some physicists hate the multiverse concept because it means that we will never have neat explanations for the fundamental numbers that govern our physical laws, which may in this grander perspective be just environmental accidents. But our preferences are irrelevant to nature. About 10 years ago I was on a panel at Stanford University where we were asked by someone in the audience how much we would bet on the multiverse concept. I said that on a scale of betting my goldfish, my dog or my life, I was nearly at the dog level.

Andrei Linde, who had spent 25 years promoting eternal inflation, said he would almost bet his life. Later, on being told this, physicist Steven Weinberg said he would happily bet my dog and Linde's life. Linde, my dog and I will all be dead before the question is settled. But none of this should be dismissed as metaphysics. It is speculative science—exciting science.

And it may be true. And what will happen to this universe—or multiverse—of ours?. Long-range forecasts are seldom reliable, but the best and most conservative bet is that we have almost an eternity ahead with an ever colder and ever emptier cosmos. Galaxies will accelerate away and disappear. All that will be left from our vantage point will be the remnants of the Milky Way, Andromeda and smaller neighbors.

Protons may decay, dark matter particles may be annihilated, there may be occasional flashes when black holes evaporate—and then silence. This possible future is based on the assumption that the dark energy stays constant. If it decays, however, there could be a “big crunch” with the universe contracting in on itself. Or if dark energy strengthens, there would be a “big rip” when galaxies, stars and even atoms are torn apart. Other questions closer to home tantalize us.

Could there be life on any of these new planets we are discovering?. Here we are still in the realm of speculation. But unless the origin of life on Earth involved a rare fluke, I expect evidence of a biosphere on an exoplanet within 20 years. I will not hold my breath for the discovery of aliens, but I think the search for extraterrestrial intelligence is a worthwhile gamble. Success in the search would carry the momentous message that concepts of logic and physics are not limited to the hardware in human skulls.

Until now, progress in cosmology and astrophysics has owed 95 percent to advancing instruments and technology and less than 5 percent to armchair theory. I expect that balance to persist. What Hubble wrote in the 1930s remains a good maxim today. €œNot until the empirical resources are exhausted, need we pass on to the dreamy realms of speculation.” There have been many particularly exhilarating eras in the past 175 years—the 1920s and 1930s, when we realized the universe was not limited to the Milky Way, and the 1960s and 1970s, when we discovered objects that defy classical physics, such as neutron stars and quasars, and clues about the beginning of time from the cosmic microwave background. Since then, the pace of advancement has crescendoed rather than slackened.

When the history of science gets written, this amazing progress will be acclaimed as one of its greatest triumphs—up there with plate tectonics, the genome and the Standard Model of particle physics. And some major fields in astronomy are just getting going. Exoplanet research is only 25 years old, and serious work in astrobiology is really only starting. Some exoplanets may have life—they may even harbor aliens who know all the answers already. I find that encouraging.